Product Description
Pygeum Bark Extract Phytosterols 2.5%~25% HPLC/GC
| Product Name |
Pygeum Bark Extract Phytosterols |
| Botanical Name |
Prunus africana L. |
| Part of Used |
Bark |
| Specification |
Standardized as Phytosterols |
| Applied Industries |
Pharmaceuticals, Nutraceuticals and Cosmeceuticals |
Pygeum Reviews
Prunus Africana, a member of the Rosaceae family, is an evergreen species found across the entire continent of Africa at altitudes of 3,000 feet or higher. It grows up to 150 feet tall. Interest in the species began in the 1700s when European travelers learned from South African tribes how to soothe bladder discomfort and treat "old man's disease" with the bark of P. africanum. Pygeum bark extract has been used in Europe since the mid-1960s to treat men suffering from benign prostatic hyperplasia (BPH). Currently, Pygeum is the most commonly used medicine in France for BPH, backed by many double-blind studies pointing to its efficacy for reducing its symptoms.
Chemical Constitution of Pyguem Bark
The active constituents of Pygeum extract include phytosterols (e.g., beta-sitosterol) that have anti-inflammatory effects by inhibiting production of pro-inflammatory prostaglandins in the prostate. Pygeum also contains pentacyclic triterpenes (ursolic and oleanic acids) that have anti-edema properties, and ferulic acid nesters (n-docosanol and tetracosanol) that reduce prolactin levels and block the accumulation of cholesterol in the prostate.
Health Benefits of Pyguem Bark Extract
Although researches on the health benefits of taking Pyguem Bark Extract are limited, some studies suggest that Pyguem Bark Extract may offer certain health benefits. Here's a look at several key study findings:
Reducing BPH Symptoms
Clinical trials suggest that pygeum can safely and effectively help to reduce the symptoms of benign prostatic hyperplasia. In a multicenter trial in Europe, 85 men with mild to moderate benign prostatic hyperplasia were given 50 mg of pygeum twice daily for two months. The study participants demonstrated a 40% decrease in the International Prostate Symptom Score, a subjective assessment of the severity of symptoms of benign prostatic hyperplasia. Furthermore, the pygeum-supplemented men reported a 32% decrease in frequency of nocturnal urination (nocturia) and a 31% improvement in quality of life. After the supplementation with pygeum ended, the patients were followed for one additional month. The benefits derived from the pygeum therapy continued even during this period without treatment, indicating a lasting therapeutic effect.
In a larger placebo-controlled, double-blind study, 263 men received either 100 mg of pygeum or placebo daily for 60 days. The pygeum group demonstrated a 17.2% improvement in urinary flow, a 24.5% decrease in residual bladder volume, a 31% decrease in nocturia, and a 19.4% decrease in daytime urinary frequency. Overall, 66% of the pygeum group reported improvement, compared to only 31% of the placebo group.
Additional Benefits of Pygeum
Pygeum has also been used to treat inflammation of the prostate, or prostatitis. Prostatitis can occur due to infectious or non-infectious causes, and may cause symptoms such as urinary frequency, urgency, or pain. In a clinical trial, 47 patients with chronic prostatitis received 100 mg of pygeum daily for five to seven weeks. Eighty-nine percent reported a complete remission of symptoms.
In another study, men with sexual dysfunction due to either benign prostatic hyperplasia or chronic prostatitis received pygeum extract (200 mg daily for 60 days) either alone or with anti-biotics. The men receiving pygeum bark extract experienced improved sexual function, even though there were no significant differences between hormone levels or nocturnal penile rigidity before and after therapy. Based on their findings, the researchers believe that pygeum may be beneficial to patients with sexual or reproductive dysfunction.
Pyguem Bark Extract Side effects
The majority of the studies report an absence of any significant adverse effects of Pygeum, although there have been rare complaints of diarrhea, constipation, dizziness, gastric pain, and visual disturbances. One study demonstrated continued satisfactory safety profiles in 174 human subjects after 12 months of 100 mg daily doses. Toxicological studies have likewise shown very good tolerability after oral administration.Administration of Pygeum to dog and rat subjects equivalent to 560 times the therapeutic dose for six-month periods resulted in no adverse effects on hematological, biochemical, or anatomical/pathological parameters. The extract had no effect on fertility in male rats and rabbits at doses up to 80 mg/kg/day - a safety margin of 50 times the therapeutic dose. Furthermore, in vivo and in vitro mutagenicity studies showed a complete absence of mutagenic or clastogenic potential. In fact, many of the constituents of Pygeum have anticarcinogenic and antimutagenic properties in vitro and in vivo.
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