| Product Name |
Natto Extract |
| Botanical Name |
Bacillus subtilis Natto |
| Part of Used |
Seed |
| Specification |
Nattokinase 2000FU~20000FU |
| Applied Industries |
Pharmaceuticals, Nutraceuticals and Cosmeceuticals |
Natto Reviews
Natto is a traditional Japanese food, prepared by fermenting boiled soybeans with the bacterium Bacillus subtilis. Nattokinase is an enzyme, which breaks down protein, and is purified from the cheese-like natto. Nattokinase was discovered in 1980 by a researcher who was trying to identify a natural agent that could successfully dissolve clots. People throughout Asia have consumed soybeans in a variety of traditional foods (including natto) for over 1,000 years. Due to their possible contribution to the observed low rates of heart disease in Asian countries, soy products such as natto have recently attracted attention in the West. As a result, nattokinase is a popular health food supplement. Nattokinase has been reported to have blood-thinning effects. Recently, research has indicated that nattokinase may have potential in the treatment of vein clots, or deep venous thrombosis (DVT), and high blood pressure, when used in combination with the standard therapies for these conditions.
How Natto Extract Nattokinase Works
Nattokinase is widely recognized for its potent fibrinolytic properties, and can dissolve dangerous blood clots through a variety of mechanisms. In this respect, nattokinase acts much like our body's own naturally-produced fibrin-degrading enzyme known as plasmin. Human plasmin is found in the blood and serves as a defense system against hazardous blood clots associated with cardiovascular disease and stroke. Nattokinase also shares a similar clot-dissolving mechanism with other commonly-used thrombolytic drugs. However, nattokinase is much cheaper and carries a lower risk of side effects.
Health Benefits of Natto Extract Nattokinase
Although researches on the health benefits of taking Natto Powder Extract Nattokinase are limited, some studies suggest that Natto Powder Extract Nattokinase may offer certain health benefits. Here's a look at several key study findings:
Fibrinolytic and Anti-Thrombotic Activity of Nattokinase
Although the human body produces a number of enzymes that promote the growth of a thrombus (blood clot), the only natural enzyme that works to breaks down the thrombus is called plasmin. Since nattokinase is similar in molecular structure to plasmin, it makes sense that it would also have a similar mechanism of action. However, in addition to having direct fibrinolytic actions (like plasmin),18 nattokinase can also increase the body's own production of plasmin, as well as several other agents that assist in dissolving blood clots (e.g., urokinase).
Nattokinase has been shown to be effective for preventing the unwanted formation of blood clots in the legs (DVT) after a 7-8 hour airplane flight. In light of the data supporting nattokinase, Dr. Martin Milner from the Center for Natural Medicine in Portland has stated that nattokinase is not only highly effective in breaking down a thrombus, but seems to be even more potent than the traditional "clot-busting" drugs (i.e., Tissue plasminogen activatortPA). In fact, nattokinase is considered to be the most potent fibrinolytic enzyme ever discovered.
Cardiovascular Health Benefits
In addition to its ability to fight stroke, nattokinase has a number of other actions that benefit the cardiovascular system. For example, nattokinase has been shown to reduce blood pressure by inhibiting the angiotensin II converting enzyme (ACE). Reductions in blood pressure are well known to decrease your risk of cardiovascular disease.
Nattokinase has also shown promise for the treatment of hyperlipidemia. Nattokinase has also been suggested for preventing atherosclerosis and it's more general form, arteriosclerosis. Atherosclerosis is a disorder in which the arterial walls harden and narrow.
Immunomodulatory Effects
A 2012 study conducted among mice has demonstrated that nattokinase is able to enhance the immune function of macrophages. Macrophages are a type of white blood cell responsible for engulfing foreign substances that may be threatening to the body. As such, macrophages act as a security system, alerting the immune system to foreign invaders.
There is also some evidence that suggests that the active bacteria found in natto may indirectly induce the production of cytokines in the intestinal mucosa. This is important because cytokines (e.g., interleukins, interferons, and growth factors) act as protein messengers, allowing immune cells to communicate with each other in order to mount an appropriate immune response.
Given the promising results of this animal study, it is expected that further human studies will be designed to demonstrate nattokinase's beneficial effects on the immune system.
Additional Health Benefits
Most people who research nattokinase are amazed by the sheer number of potential health benefits it is associated with. For instance, it has been suggested that nattokinase may benefit conditions like diabetes, which often leads to excess platelet aggregation. Nattokinase may also be beneficial for senile dementia, which is characterized by cerebral thrombi formation as well as poor circulation/blood supply. Further potential health benefits of nattokinase include reducing chronic migraine, fibromyalgia, chronic fatigue syndrome, Lyme disease, and menstrual cramps. Some studies even suggest that natto may display activity against tumor growth.
Natto Extract Nattokinase Side effects
Natto Powder Extract Nattokinase is likely safe without any side effects and there is no known interaction with current medicines.
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